T-cell clones and T-cell receptors

Islet-specific T-cell clones from nonobese diabetic mice express heterogeneous T-cell receptors.

Nonobese diabetic (NOD) mice spontaneously develop a T-cell-mediated autoimmune disease that is similar in many respects to insulin-dependent diabetes mellitus in humans. T-cell clones that specifically recognize pancreatic islet cell antigens can be derived from NOD mice, and most of these have been diabetogenic upon transfer to healthy recipients. We report herein the sequences of the T-cell ...

1436 Tolerance in T Helper Cell Clones

From the Division of Immunologic Oncology, Lombardi Cancer Research Center, Georgetown University School of Medicine, Washington D.C. 20007," the Department of Immunology and the Committee for the Study of Molecular Genetics, Research Institute of Scripps Clinic, LaJolla, California 92037; and the Imperial Cancer Research Fund, Tumour Immunology Unit, Department of Zoology, University College L...

Influenza nucleoprotein-specific cytotoxic T-cell clones

Influenza nucleoprotein (NP) serves as a target antigen on abortively infected cells for cytotoxic T cells (TJ) cross-reactive for all type A influenza viruses, and it can also prime mice for such Tc. It is important to test the protective ability of NP-specific Tc clones in vivo in a productive influenza infection. In this report, we show that Tc clones of this antigenic specificity protect mi...

Panel of Human Proliferative T Cell Clones'

Functional gamma chain-associated T cell receptors on cerebrospinal fluid-derived natural killer-like T cell clones

We have derived 33 independent T cell clones from the cerebrospinal fluid (CSF) of a patient with subacute sclerosing panencephalitis using a single T cell cloning method. 6% (2 of 33) of these clones express the T cell receptor gamma (TCR-gamma) protein and are called CSF TCR-gamma clones. Phenotypic analyses of the CSF TCR-gamma clones indicate that they are WT-31-, CD3+, CD4-, and CD8-. The ...